Nauclea Latifolia (African Peach) Attenuates Gastric Acid Secretionin Rats with Ethanol-Induced Ulceration

Authors

  • Morufu Eyitayo Balogun Department of Physiology, Faculty of Health Sciences, Al-Hikmah University Ilorin, Kwara State, Ilorin 240212, Nigeria Author
  • Grace Ottah Umahi Department of Physiology, Faculty of Basic Medical Sciences, Ebonyi State University, Ebonyi State, Abakaliki 480214, Nigeria Author
  • Taofeek Olanrewaju Ayinde Department of Physiology, Faculty of Basic Medical Sciences, University of Ilorin, Kwara State, Ilorin 240003, Nigeria Author
  • Amuda Oluwasola Department of Physiology, Faculty of Health Sciences, Al-Hikmah University Ilorin, Kwara State, Ilorin 240212, Nigeria Author
  • Akeem Olayinka Busar Department of Medical Laboratory Science, Faculty of Health Sciences, Al-Hikmah University Ilorin, Kwara State, Ilorin 240212, Nigeria Author
  • , Kabiru Adewale Ajibola Department of Medical Laboratory Science, Faculty of Health Sciences, Al-Hikmah University Ilorin, Kwara State, Ilorin 240212, Nigeria Author
  • Raufu Olanrewaju Yusuf Department of Environmental Health Sciences, Faculty of Pure and Applied Sciences, Kwara State University, Kwara State, Malete 241104, Nigeria Author
  • Lekan Sheriff Ojulari Department of Physiology, Faculty of Basic Medical Sciences, University of Ilorin, Kwara State, Ilorin 240003, Nigeria Author

Keywords:

Nauclea latifolia, Antacid, Antisecretory, Ethanol , Gastric ulcers, Rats

Abstract

Objective: The ethanolic leaf extract of N. latifolia (EENL) was investigated
for its gastric acid antisecretory effects on ethanol-induced gastric ulcerated
rats using an in vivo assay. Methods: Gastric mucosal ulceration was induced
experimentally in Groups 2 to 5 rats using ethanol. Five groups of rats were
orally pretreated with 3% Tween-80 only as vehicle group, 3% Tween-80 as
ulcer group, 20 mg/kg of omeprazole as positive group, 250 and 500 mg/kg
of EENL as the test groups, respectively before ulcer induction. Gastric acid
secretion parameters and ulcerated areas were evaluated. Results:
Pretreatment with EENL showed significant (P < 0.05) reduction in gastric
volume, total acidity and ulcer index while the pH of gastric content increased
significantly (P < 0.05) in rats with ethanol-induced ulcer. Ulcer group
exhibited significantly severe mucosal injury and EENL or omeprazole
offered significant (P < 0.05) protection against gastric mucosal injuries.
Conclusion: The study suggests that EENL attenuates gastric acid secretion
and ulceration induced by ethanol in Wistar rat. The observed
pharmacological activities might be mediated via antisecretory and
cytoprotective mechanisms. 

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Published

2025-05-20

Issue

Vol. 1 No. 1 (2021): AJOHS

Section

Articles