Authors
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Olatunbosun, L.O
Department of Haematology and Blood Transfusion, University of Ilorin Teaching Hospital, Ilorin, PMB 1459, Kwara State, Nigeria. P.O BOX 4173, POST CODE 240001, PMB 1515
Author
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Khalil, E.A.G
Department of Clinical Pathology & Immunology, Institute of Endemic Diseases, University of Khartoum, 11115, Sudan
Author
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Olalere, F.D.
Department of Haematology and Blood Transfusion, University of Ilorin Teaching Hospital, Ilorin, 240001, Nigeria.
Author
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Atunwa, S.A.
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin, 240003, Nigeria
Author
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Lawal, S.A
Department of Haematology, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, 240003, Nigeria
Author
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Biliaminu, S.A
Department of Chemical Pathology and Immunology, University of Ilorin/University of Ilorin Teaching Hospital, Ilorin, 240001, Nigeria
Author
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Ibrahim, S.E.
Department of Chemical Pathology and Immunology, University of Ilorin Teaching Hospital, Ilorin, 240001, Nigeria
Author
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Shittu, A.O.
Department of Haematology, University of Ilorin/ University of Ilorin Teaching Hospital, Ilorin, 240001, Nigeria.
Author
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Busari, A.O
Department of Medical Laboratory Science, Faculty of Health Sciences, Al-Hikmah University, Ilorin, Nigeria
Author
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Olawuyi, A.O.
Department of Medical Laboratory Science, Faculty of Health Sciences, Al-Hikmah University, Ilorin, Nigeria
Author
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Muhammed, T.O
Department of Medical Laboratory Science, Faculty of Health Sciences, Al-Hikmah University, Ilorin, Nigeria
Author
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Afolabi, O.O.
Department of Histopathology, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, 240001, Nigeria.
Author
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AbdulRaheem, A.A
Department of Haematology and Blood Transfusion, University of Ilorin Teaching Hospital, Ilorin, 240001, Nigeria
Author
Keywords:
Differentiation-enhancing effects, Parquetina nigrescens, Camellia sinensis, Telfairia occidentalis, Haemopoietic, Multipotent Stem Cells
Abstract
Objective: This study investigated the probable haemopoietic multi-stem cells differentiation enhancing effects of Parquetina nigrescens, Camellia sinensis and Telfairia occidentalis leaves extracts. Materials and Methods: Haemopoietic bone marrow stem cells from irradiated guinea pigs were harvested on day 13th post-irradiation, cultured and treated with varying concentrations (0.313-100%) of aqueous leaf extracts of each of the plant extracts. The degree of differentiation was determined by MTT assay. Results: The degree of differentiation was highest in Telfairia occidentalis, followed by Camellia sinensis and Parquetina nigrescens respectively. Combination of the three plants showed a synergistic stimulatory effect on cell differentiation. Also, strong positive correlation between the concentrations of each of the extract of the three plants and the degree of differentiation. Conclusion: Camellia sinensis, Telfairia occidentalis and Parquetina nigrescens leaves extracts have positive differentiation enhancing effects on haemopoietic multi-potent stem cells individually and when combined.
