In-Vitro Variations in Erythrocyte Ageing Among Different Categoriesof Blood Donors Due to Donor-Related Factors

Authors

  • Sikiru Adetona Lawal Department of Hematology and Blood Transfusion, University of Ilorin Teaching Hospital, Ilorin, PMB 1459, Kwara State, Nigeria. P.O BOX 4173 Author
  • Daniel Ohilebo Ugbomoiko Department of Medical Laboratory Science, Igbinedion University Okada, Edo State, 302110, Nigeria Author
  • Musa Abidemi Muhibi Department of Medical Laboratory Science, Edo State University, Uzairue. Edo State, 312107, Nigeria. Author
  • Luqman Olayinka Olatunbosun Department of Hematology and Blood Transfusion, University of Ilorin Teaching Hospital, Ilorin, 240001, Nigeria Author
  • Abiola Samuel Babatunde, Fatai Dayo, Ameenah Ayodeji AbdulRaheem , Rasheed Oladimeji Lambelalere , Department of Hematology and Blood Transfusion, University of Ilorin Teaching Hospital, Ilorin, 240001, Nigeria Author
  • Tajudeen Kolawole Ogunwale , Sulaeman Eleha Ibrahim Department of Chemical Pathology and Immunology, University of Ilorin Teaching Hospital, Ilorin, 240001, Nigeria Author
  • Ibrahim Kehinde Lawal Department of Science Laboratory, Osun State Polytechnic, Esa Oke, Osun State, 233130, Nigeria. Author

Keywords:

Donation, Frequency, Family, Remunerated, Lesions, Biomarkers

Abstract

Blood storage lesion is a rapidly growing area of biomedical research which leaves several
questions unanswered. This study assessed blood donation frequency, as it affects
hematological and biochemical parameters among different categories of blood donors
longitudinally over a period of 35 days at 2-6
0C. Ethically approved cross-sectional
research involving family (n=30), remunerated donors: mild (n=30), moderate (n=30) and
high frequency (n=30). One hundred milliliters (100 mL) of well-mixed blood was
transferred into the satellite bag from 450mls of blood from different categories of blood
donors. Haemogram, plasma Ferritin, Erythropoietin (EPO), 2, 3-diphosphoglycerate,
Sodium (Na+
) and Potassium (K+
) assessed at 0, 7, 14, 21, 28 and 35 days of storage were
analyzed. This study revealed acceptable normal high values in Haemogram,
erythropoietin and ferritin in family donors while Remunerated donors had mild to
moderate anemia, high total WBC count, higher platelet count, a very low ferritin content,
low red cell indices, high EPO, hypernatremia, hyperkalaemia and high 2, 3.
Diphosphoglycerate (2, 3, DPG). Significant iron deficiency anemia and electrolyte
imbalance among moderate to high frequent blood donors. 

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Published

2025-05-23

Issue

Vol. 1 No. 1 (2021): AJOHS

Section

Articles