Haemopoietic Potentials of the Aqueous Leaf Extract of VernoniaAmygdalina on Haematological Parameters in PhenylhydrazineInduced Anaemic Wistar Rats

Abstract

Anaemia is the most prevalent nutritional deficiency disorder in the world; it is defined
as a condition by which the haemoglobin content of blood is lower than normal as a
result of deficiency of one or more essential nutrients.
Objective: This study examined haemopoietic potentials of aqueous leaf extract of
Vernonia amygdalina on haematological parameters in phenylhydrazine induced
albino wistar rats.
Materials and Methods: Thirty (30) wistar rats were grouped into five (5) groups of
six (6) rats per group. The phenylhydrazine was used to induce anaemia intraperitonially and aqueous extract of Vernonia amygdalina was administered orally for
14 days at different concentrations of 100 mg/ kg, 200 mg/kg and 400 mg/kg with
Normal and Negative controls). A volume of 5mls of blood sample was collected and
analysed for haematological parameters using Haematology Autoanalyzer.
Results: The mean and standard deviation of HGB g/dl, PCV %, RBC x 1012/L and
WBC x 109
/L of the treated groups were expressed as (8.45 ± 0.54 to 13.20 ± 0.32),
(23.50 ± 2.38 to 40.50 ± 4.65), (4.09 ± 0.26 to 7.33 ± 0.76) and (24.90 ± 8.08 to 12.43
± 1.63) respectively in relation with the control groups which showed significant
difference (p<0.05) in their profile when compared with the control groups.
Conclusion: It was revealed that the plant possesses erythropoietic properties
according to the results of some haematological parameters.