Authors
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Olatunbosun, L.O
Department of Haematology and Blood Transfusion, University of Ilorin Teaching Hospital, Ilorin, 240001, Nigeria.
Author
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Khalil, E.A.G
Department of Clinical Pathology & Immunology, Institute of Endemic Diseases, University of Khartoum, 11115, Sudan
Author
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Olalere, F.D
Department of Haematology and Blood Transfusion, University of Ilorin Teaching Hospital, Ilorin, 240001, Nigeria
Author
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Atunwa, S.A
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin, 240003, Nigeria
Author
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Lawal, S.A
Department of Haematology, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, 240003, Nigeria.
Author
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Biliaminu, S.A
Department of Chemical Pathology and Immunology, University of Ilorin/University of Ilorin Teaching Hospital, Ilorin, 240001, Nigeria
Author
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Suleiman, Ibrahim Eleha
Department of Haematology, University of Ilorin/ University of Ilorin Teaching Hospital, Ilorin, 240001, Nigeria.
Author
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Shittu, A.O.
Department of Haematology, University of Ilorin/ University of Ilorin Teaching Hospital, Ilorin, 240001, Nigeria.
Author
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Busari, A.O.
Department of Medical Laboratory Science, Faculty of Health Sciences, Al-Hikmah University, Ilorin, Nigeria
Author
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, Olawuyi, A.O
Department of Medical Laboratory Science, Faculty of Health Sciences, Al-Hikmah University, Ilorin, Nigeria
Author
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, Muhammed, T.O.
8Department of Medical Laboratory Science, Faculty of Health Sciences, Al-Hikmah University, Ilorin, Nigeria
Author
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Afolabi, O.O.
Department of Histopathology, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, 240001, Nigeria
Author
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AbdulRaheem, A.A
Department of Haematology and Blood Transfusion, University of Ilorin Teaching Hospital, Ilorin, 240001, Nigeria.
Author
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Lawal, I.K
Department of Science Laboratory, Osun State Polytechnic, Esa Oke, Osun State, 233010, Nigeria.
Author
Keywords:
Differentiation-enhancing effects, Parquetina nigrescens, Camellia sinensis, Telfairia occidentalis, Haemopoietic, Multipotent Stem Cells
Abstract
Objective: This study investigated the probable haemopoietic multi-stem cells
differentiation enhancing effects of Parquetina nigrescens, Camellia sinensis
and Telfairia occidentalis leaves extracts. Materials and Methods:
Haemopoietic bone marrow stem cells from irradiated guinea pigs were
harvested on day 13th post-irradiation, cultured and treated with varying
concentrations (0.313-100%) of aqueous leaf extracts of each of the plant
extracts. The degree of differentiation was determined by MTT assay. Results:
The degree of differentiation was highest in Telfairia occidentalis, followed by
Camellia sinensis and Parquetina nigrescens respectively. Combination of the
three plants showed a synergistic stimulatory effect on cell differentiation.
Also, strong positive correlation between the concentrations of each of the
extract of the three plants and the degree of differentiation. Conclusion:
Camellia sinensis, Telfairia occidentalis and Parquetina nigrescens leaves
extracts have positive differentiation enhancing effects on haemopoietic multipotent stem cells individually and when combined.
