Authors
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Godwin O. Adunmo
Department of Medical Laboratory Science, University of Ilorin, Kwara State, 240003, Nigeria
Author
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Oyebola Ganiyu Adeosun
Department of Medical Laboratory Science, University of Medical Sciences Ondo, Ondo State, 351104, Nigeria
Author
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Franklin Folasele Akinola
Department of Biomedical Sciences, Ladoke Akintola University of Technology Ogbomoso, Oyo State, 210214, Nigeria
Author
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Idris Yahaya Mohammed
Department of Chemical Pathology, Bayero University Kano, Kano State, 700233, Nigeria
Author
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, Muhammad Bello Ahmad
Department of Medical Laboratory Science, Bayero University Kano, Kano State, 700233, Nigeria
Author
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Simeon Makinde Ogundiran
Coffey County Hospital, Burlington, Kansas 66839 USA
Author
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Kamoru Ademola Adedokun
King Saud University, 11545, DUH, Riyadh, Kingdom of Saudi Arabia, 60169
Author
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, Kolawole Tajudeen Ogunwale
Department of Chemical Pathology and Immunology, University of Ilorin Teaching Hospital, Kwara State, 240001, Nigeria
Author
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Abubakar Z. Lawal
Department of Medical Biochemistry, College of Health Science, University of Ilorin, Kwara State, 24003, Nigeria
Author
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Akeem Olayinka Busari
Department of Medical Laboratory Science, Faculty of Health Sciences, Al-Hikmah University Ilorin, Kwara State, Ilorin 240212, Nigeria
Author
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Niyi Abdulgafar Popoola
Department of Medical Laboratory Science, Kwara State University Malete, Kwara State, 241103, Nigeria
Author
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Wasiu Olanrewaju Garuba
Department of Medical Laboratory Science, Kwara State University Malete, Kwara State, 241103, Nigeria
Author
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, Munirudeen Ibrahim
Department of Medical Laboratory Science, Kwara State University Malete, Kwara State, 241103, Nigeria
Author
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Morufu Eyitayo Balogun
Department of Physiology, Al-Hikmah University Ilorin, Kwara State, 240212, Nigeria
Author
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Moshood Bolaji
Department of Veterinary Pathology, University of Ilorin, Kwara State, 240003, Nigeria
Author
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Shefiat Bashir
Department of Medical Laboratory Science, Al-Hikmah University Ilorin, Kwara State, 240212, Nigeria
Author
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Fatimoh Abimbola Salau
Department of Medical Laboratory Science, Kwara State University Malete, Kwara State, 241103, Nigeria
Author
Keywords:
Ocimum gratissimum, Electrolytes, Urea, Creatinine
Abstract
Humans have given the leaves of Ocimum gratissimum (O. gratissimum) a great deal
of attention due to their vast medical usefulness, culinary application, and
pharmacological effects. As a result, the study evaluated the effect of O. gratissimum
on renal profile of male Wistar rats. Ten healthy male Wistar rats were randomized into
test and control groups comprising of 5 animals each. The test group received
400mg/Kg O. gratissimum leaf extract whereas the control group was fed with normal
rat diet and water. The rats were euthanized through cervical dislocation at the end of
the experiment and blood sample was collected through heart puncture for serum
assessment renal profile while the kidney was excised for histological examination.
The Results showed a non-significant at p>0.05 increase in serum electrolytes and urea
while significant at p<0.05 decrease in the mean serum creatinine level was observed
in the test group compared to the control group. Also, the histological examination of
the kidney tissue revealed a mild lymphocytic infiltration in the test group compared to
the control group. Conclusively, the study suggested a dose-dependent toxicological
effect of O. gratissimum on renal profile.
