Authors
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Akeem Olayinka Busari
Department of Medical Laboratory Science, Faculty of Health Sciences, Al-Hikmah University Ilorin, Kwara State, Nigeria
Author
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Temitope Ayobami Onamadi
Department of Medical Laboratory Science, Kwara State University Malete, Kwara State, 241104, Nigeria
Author
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Munirudeen Ibrahim
Department of Medical Laboratory Science, Kwara State University Malete, Kwara State, 241104, Nigeria
Author
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Munirudeen Ibrahim
Department of Medical Laboratory Science, Kwara State University Malete, Kwara State, 241104, Nigeria
Author
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Morufu Eyitayo Balogun
Department of Physiology, Al-Hikmah University Ilorin, Kwara State, 240212, Nigeria.
Author
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Wasiu Olanrewaju Garba
Department of Medical Laboratory Science, Kwara State University Malete, Kwara State, 241104, Nigeria
Author
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Kolawole Tajudeen Ogunwale
Department of Chemical Pathology and Immunology, University of Ilorin Teaching Hospital, Kwara State, 240001, Nigeria
Author
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Godwin O. Adunmo
Department of Medical Laboratory Science, University of Ilorin, Kwara State, 240003, Nigeria
Author
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Muhammed Bello Ahmad
Department of Medical Laboratory Science, Bayero University Kano, Kano State, 700241, Nigeria
Author
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Idris Yahaya Mohammed
Department of Chemical Pathology, Bayero University Kano, Kano State, 700241, Nigeria
Author
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Sulaiman Adebayo Nassar
Department of Biomedical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, 210214, Nigeria
Author
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Franklin Folasele Akinola
Department of Biomedical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, 210214, Nigeria
Author
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, Niyi Abdulgafar Popoola
Department of Medical Laboratory Science, Kwara State University Malete, Kwara State, 241104, Nigeria
Author
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Abubakar Zubair Lawal
Department of Medical Biochemistry, University of Ilorin, Kwara State, 240003, Nigeria
Author
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Maroof Gbadebo Oyeniyi
Department of Medical Laboratory Science, General Hospital Offa, Kwara State, 250101, Nigeria
Author
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Suleiman Eleha
Department of Chemical Pathology and Immunology, University of Ilorin Teaching Hospital, Kwara State, 240001, Nigeria
Author
Keywords:
Hypertension, Normotension, Creatine Kinase , Lactate dehydrogenase
Abstract
The main factor contributing to morbidity and mortality is hypertension. Although blood
pressure is a complicated feature, studies have shown that the activity of adenosine triphosphate
(ATP)-generating enzymes like creatine kinase (CK) and lactate dehydrogenase (LDH) is a
major predictor of hypertension. As a result, this study evaluated the activities of CK and LDH
activities in hypertensive patients attending the General Hospital Ilorin, Kwara State. One
hundred and sixty-one (161) hypertensive patients and thirty-nine (39) normotensive subjects
were recruited into a case-control study of 200 participants. Body mass index (BMI) was
estimated from each participant's measured weight and height, while the blood pressure was
determined from the measured systolic blood pressure (SBP) and diastolic blood pressure (DBP)
using conventional mercury sphygmomanometer. A 5 mls sample of blood was taken from each
subject, and the extracted serum was analyzed using an enzymatic-kinetic method to quantify
the CK and LDH activities. Results showed that hypertensive patients had significantly at p
<0.05 higher serum CK and LDH activities in hypertensive compared to apparently healthy
normotensives. Thus, this study observed significantly increase CK and LDH activities in
hypertensive patients.
